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Piracetam Dosage for the Common Person
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Paroxetine is a selective serotonin-reuptake inhibitor [5-HT 4 receptor antagonist]. It enhances mood and improves feelings of well-being.
Paroxetine is a monoamine oxidase inhibitor (MAOI) with a half-life of 40 to 60 minutes for most adults and 100 to 120 minutes for those over 65. It has a mechanism of action that involves increased availability of tryptophan (a key buspirone online uk
amino acid precursor for serotonin and norepinephrine), inhibited enzymatic degradation of some serotonin and norepinephrine an increase in the production of neurotransmitter noradrenaline.
Paroxetine also has the distinct property of lowering blood levels the following:
Serotonin and norepinephrine (reuptake inhibition)
Serotonin and dopamine (reuptake inhibition)
Dopamine (reuptake inhibition)
Adenosine (reuptake inhibition)
Norepinephrine (reuptake inhibition)
Phenylethylamine (reuptake inhibition)
L-Carnitine (reuptake inhibition)
L-Tyrosine (reuptake inhibition)
L-Thymoside (reuptake inhibition)
Folic Acid (molecular weight of 955) has also been shown to have a direct neuroprotective effect and the administration of folic acid has also been shown to inhibit MAO activity.
Paroxetine is used alone or in combination with other drugs to treat:
Obsessive-compulsive disorders (OCD/tics panic attacks)
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patterns caused by psychiatric disorders (especially depression and/or anxiety-related disorders)
Dry mouth/difficulty swallowing that does not improve with water
Irritability/increased buspirone buy uk aggressiveness
Obsessive-compulsive disorder (OCD)
Severe or chronic pain
Alcoholism or drug abuse
Cognitive disorders (such as attention deficit disorders, autism spectrum disorder, dementia)
Panic attacks in children under 12
Clinical Trials for Paroxetine
Trial #: CTA-161802
Study Design: Randomized, double-blind, placebo-controlled
Population: Patients with OCD, ADHD, and MDD
Intervention: Paroxetine 20mg daily
Main Outcome Measurements: Clinician-reported Global Improvement Scale (CGI-S), clinical impression of change- (CGI-C), Montgomery -Asberg Depression Rating Scale-CGI, Yale Global Impression of Change Scale/YGIC-C, and visual analog scale (VAS)
Result: No significant difference in improvement clinical global impression of change or CGI-C, YGIC-C, and VAS was found; scores increased from baseline to posttreatment of 19.5% versus 17.9% for the placebo group.
Conclusion: Paroxetine was associated with clinical improvement in OCD and ADHD was not associated with any improvements in other clinical measures of severity in patients with MDD.
Trial #: CTA-161812
Study Design: Double-blind, placebo-controlled, parallel-group, multicenter study.
Intervention: paroxetine 20mg daily, plus sertraline 50mg/day
Main Outcome Measurements: Clinician-reported Global Improvement Scale (CGI-S), clinical impression of change- (CGI-C), Montgomery-Asberg Depression Rating Scale-CGI, and visual analog scale (VAS)
Result: Greater improvement in clinical global evaluation and CGI-S scores with sertraline, whereas a difference was not observed in the other measures of severity.
Conclusion: Patients with OCD, ADHD, and MDD who receive paroxetine alone do not experience a Order amitriptyline online uk
significant improvement in clinical global evaluation and CGI-S, whereas patients who take paroxetine plus sertraline do show a significant improvement in.
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